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Clin Pharmacol Ther. 2019 Sep 27. doi: 10.1002/cpt.1636. [Epub ahead of print]

Risk of myocardial infarction among new users of calcium supplements alone or combined with vitamin d: a population-based case-control study.

Author information

1
Clinical Pharmacology Unit, University Hospital Príncipe de Asturias, Alcalá de Henares, Madrid, Spain.
2
Department of Biomedical Sciences (Pharmacology Sector), University of Alcalá, Alcalá de Henares, Madrid, Spain.
3
Pharmacoepidemiology Research Group, Institute for Health Research IRYCIS, Madrid, Spain.
4
Division of Pharmacoepidemiology and Pharmacovigilance, Spanish Agency for Medicines and Medical Devices, Madrid, Spain.
5
Cardiology Department, University Hospital Príncipe de Asturias, Alcalá de Henares, Madrid, Spain.
6
Department of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain.

Abstract

A population-based case-control study was conducted to evaluate the risk of acute myocardial infarction among new users of calcium supplements, alone (CaM) or in combination with vitamin D (CaD). A total of 23025 cases and 114851 controls randomly sampled from the underlying cohort and matched with cases by age, sex and index date were included. New users of CaM and CaD were categorized as current-, recent-, past- and non-users. We computed adjusted odds ratios (AOR) and their 95%CI among current users as compared to non-users through a conditional logistic regression. No increased risk was associated with CaM overall (59 cases (0.26%) and 273 controls (0.24%); AOR=0.80;0.59-1.09), nor was it found in any of the conditions examined. Instead, the use of CaD was associated with a decreased risk (275 cases (1.19%) and 1160 controls (1.45%); AOR=0.78;0.67-0.90), dose and duration-dependent, and particularly evident in patients with a high cardiovascular risk (AOR=0.59;0.43-0.81).

KEYWORDS:

acute myocardial infarction; calcium supplements; epidemiology; osteoporosis; therapeutics; vitamin D

PMID:
31560413
DOI:
10.1002/cpt.1636

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