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Curr Drug Targets. 2019 Sep 27. doi: 10.2174/1389450120666190927123746. [Epub ahead of print]

Molecular and Biological Functions of Melatonin in Endometrial Cancer.

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Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R.. Iran.
Faculty of Kinesiology, University of Calgary, Calgary, AB. Canada.
Minimally Invasive Techniques Research Center in Women, Tehran Medical Sciences Branch, Islamic Azad University, Tehran. Iran.
Pars Advanced and Minimally Invasive Medical Manners Research Center, Pars Hospital, Iran University of Medical Sciences, Tehran. Iran.
Department of Gynecology and Obstetrics, School of Medicine, Iran University of Medical Sciences, Tehran. Iran.


Endometrial cancer is the fifth leading cancer among women, this rate is higher in developed countries and its incidence is increasing worldwide. Diabetes mellitus, obesity, hypertension and arteriosclerosis are major risk factors for endometrial cancer. Melatonin is a hormone synthesized in the pineal and extra-pineal organs such as the digestive tract, bone marrow, retina and more. Evidence shows the potential effects of melatonin in endometrial cancer inhibition. Therefore, the focus of this paper is to review this outstanding evidence and to summarize the molecular and biological mechanisms of melatonin for the inhibition of endometrial cancer.


Melatonin; apoptosis; endometrial cancer; pregnancy

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