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J Nutr Health Aging. 2019;23(8):725-731. doi: 10.1007/s12603-019-1220-z.

Higher Vitamin D Levels Are Associated with Better Attentional Functions: Data from the NorCog Register.

Author information

1
J. Zugic Soares, Medical Department, Section of Geriatrics, Lovisenberg Diaconal Hospital, PB 4970 Nydalen 0440 Oslo, Norway, jelenazugic@hotmail.com.

Abstract

OBJECTIVES:

The aim of this cross-sectional study was to evaluate which cognitive domains are mostly affected in persons with vitamin D insufficiency or deficiency, defined as 25(OH)D < 50 nmol/l and < 25 nmol/l, respectively.

METHODS:

Data were collected from the Norwegian register for persons assessed for cognitive symptoms (NorCog). 580 persons aged ≥ 65 years were included. The following cognitive and neuropsychiatric tests were used: Mini Mental State Examination, Norwegian Revised Version (MMSE-NR), the Clock Drawing test, the Trail Making Test A and B, the 10-word memory test and the figure copying test from CERAD - immediate and delayed recall, The Controlled Oral Word Association Test -FAS and Boston Naming test. Neuropsychiatric symptoms were assessed by Neuropsychiatric Inventory-Questionnaire and Cornell Scale for Depression in Dementia.

RESULTS:

Vitamin D-insufficiency was found in approx. 30 % of the study cohort. After adjustment for relevant covariates, higher serum 25(OH)D levels were associated with higher score on MMSE-NR (p=0.032) and 10-word Memory Test, immediate recall (p=0.038), as well as faster execution of Trail Making Test A and B (p=0.038 and p=0.021, respectively). Other tests were not significantly associated with 25(OH)D levels.

CONCLUSION:

Higher vitamin D levels appear to be associated with better cognition, especially in areas of executive function and mental flexibility.

KEYWORDS:

Vitamin D; dementia; executive function; neurocognitive function

PMID:
31560030
DOI:
10.1007/s12603-019-1220-z

Conflict of interest statement

As potential conflicts of interest is to be mentioned that Anne-Brita Knapskog is the principal investigator in two drug trials (Roche BN29553 and Boehringer-Ingelheim 1346.0023) which are performed at the memory clinic, Department of Geriatric Medicine at Oslo University Hospital. The other authors declare no financial or other conflict of interest.

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