Format

Send to

Choose Destination
Int J Mol Sci. 2019 Sep 25;20(19). pii: E4756. doi: 10.3390/ijms20194756.

Relationship Between Intermittent Hypoxia and Type 2 Diabetes in Sleep Apnea Syndrome.

Author information

1
Second Department of Internal Medicine, Nara Medical University, Kashihara, Nara 634-8522, Japan. hiroyon@naramed-u.ac.jp.
2
Second Department of Internal Medicine, Nara Medical University, Kashihara, Nara 634-8522, Japan. ffyukio@naramed-u.ac.jp.
3
Second Department of Internal Medicine, Nara Medical University, Kashihara, Nara 634-8522, Japan. motoo@naramed-u.ac.jp.
4
Second Department of Internal Medicine, Nara Medical University, Kashihara, Nara 634-8522, Japan. smuro@naramed-u.ac.jp.
5
Department of Advanced Medicine for Pulmonary Circulation and Respiratory Failure (Donation Course), Nippon Medical School Graduate School of Medicine, Bunkyo, Tokyo 113-8602, Japan. k-hiroshi@nms.ac.jp.
6
Department of Biochemistry, Nara Medical University, Kashihara, Nara 634-8521, Japan. shintksw@naramed-u.ac.jp.

Abstract

Sleep apnea syndrome (SAS) is a very common disease involving intermittent hypoxia (IH), recurrent symptoms of deoxygenation during sleep, strong daytime sleepiness, and significant loss of quality of life. A number of epidemiological researches have shown that SAS is an important risk factor for insulin resistance and type 2 diabetes mellitus (DM), which is associated with SAS regardless of age, gender, or body habitus. IH, hallmark of SAS, plays an important role in the pathogenesis of SAS and experimental studies with animal and cellular models indicate that IH leads to attenuation of glucose-induced insulin secretion from pancreatic β cells and to enhancement of insulin resistance in peripheral tissues and cells, such as liver (hepatocytes), adipose tissue (adipocytes), and skeletal muscles (myocytes). In this review, we focus on IH-induced dysfunction in glucose metabolism and its underlying molecular mechanisms in several cells and tissues related to glucose homeostasis.

KEYWORDS:

adipokines; glucose-induced insulin secretion; hepatokines; intermittent hypoxia; myokines; pancreatic β cell proliferation; sleep apnea syndrome; type 2 diabetes

PMID:
31557884
DOI:
10.3390/ijms20194756
Free full text

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI)
Loading ...
Support Center