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Front Psychiatry. 2019 Aug 29;10:615. doi: 10.3389/fpsyt.2019.00615. eCollection 2019.

Psychological Resilience Enhances the Orbitofrontal Network in the Elderly With Mild Cognitive Impairment.

Author information

1
Department of Psychiatry, Ajou University School of Medicine, Suwon, South Korea.
2
Department of Biomedical Informatics, Ajou University School of Medicine, Suwon, South Korea.
3
Office of Biostatistics, Ajou University School of Medicine, Suwon, South Korea.
4
Department of Radiology, Ajou University School of Medicine, Suwon, South Korea.
5
Department of Brain Science, Ajou University School of Medicine, Suwon, South Korea.
6
Department of Psychiatry, The Catholic University of Korea College of Medicine, Yeouido St. Mary's Hospital, Seoul, South Korea.

Abstract

Background: It has been suggested that maintaining the efficient organization of the brain's functional connectivity (FC) supports neuroflexibility under neurogenerative stress. This study examined psychological resilience-related FC in 112 older adults with mild cognitive impairment (MCI). Methods: Using a resting-state functional magnetic resonance imaging (fMRI) approach, we investigated reorganization of the orbitofrontal gyrus (OFG)/amygdala (AMG)/hippocampus (HP)/parahippocampal gyrus (PHG) FC according to the different levels of resilience scale. Results: Compared with the low resilient group, the high resilient group had greater connectivity strengths between the left inferior OFG and right superior OFG (P < 0.05, Bonferroni corrected), between the right inferior OFG and left PHG (P < 0.05, Bonferroni corrected), and between the right middle OFG and left PHG (false discovery rate < 0.05). Conclusion: Psychological resilience may be associated with enhancement of the orbitofrontal network in the elderly with MCI.

KEYWORDS:

elderly; fMRI; functional connectivity; orbitofrontal cortex; resilience

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