Format

Send to

Choose Destination
Biomark Med. 2019 Sep 25. doi: 10.2217/bmm-2019-0315. [Epub ahead of print]

Levels of oligomeric α-Synuclein in reflex tears distinguish Parkinson's disease patients from healthy controls.

Author information

1
Department of Ophthalmology & Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
2
Department of Pharmacology & Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA.
3
Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
4
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.

Abstract

Aim: Due to active engagement of sensory and afferent nerve fibers in reflex tearing which could be affected in Parkinson's disease (PD), we tested reflex tears as a source of potential PD biomarkers. Patients & methods: Reflex tears collected from 84 PD and 84 age- and sex-equivalent healthy controls (HC) were used to measure levels of oligomeric α-Synuclein (α-SynOligo), total α-Synuclein (α-SynTotal), C-C motif chemokine ligand 2, protein deglycase (DJ-1), lactoferrin and matrix metalloproteinase 9. Results: α-synOligo (p < 0.0001), C-C motif chemokine ligand 2 (p = 0.003) and lactoferrin (p = 0.002) were significantly elevated in PD patient tears relative to HC tears. Tear flow was significantly lower in PD relative to HC (p = 0.001). Conclusion: Reflex tears are a potential source for detection of characteristic changes in PD patients.

KEYWORDS:

Parkinson's disease; biomarker; diagnosis; oligomeric α-Synuclein; tears; α-Synuclein

PMID:
31552762
DOI:
10.2217/bmm-2019-0315
Free full text

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center