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Nat Neurosci. 2019 Oct;22(10):1617-1623. doi: 10.1038/s41593-019-0471-7. Epub 2019 Sep 24.

Common brain disorders are associated with heritable patterns of apparent aging of the brain.

Author information

1
NORMENT, Division of Mental Health and Addiction Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway. bias.kaufmann@medisin.uio.no.
2
NORMENT, Division of Mental Health and Addiction Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
3
School of Mental Health and Neuroscience Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.
4
Department of Psychiatry and Psychotherapy Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
5
Department of Psychiatry Diakonhjemmet Hospital, Oslo, Norway.
6
Centre for Psychiatry Research, Department of Clinical Neuroscience Karolinska Institutet & Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.
7
Department of Psychological and Brain Sciences, Washington University in St. Louis, St. Louis, USA.
8
Department of Psychiatry Washington, University in St. Louis, St. Louis, USA.
9
Department of Radiology Washington, University in St. Louis, St. Louis, USA.
10
Department of Psychology I, University of Würzburg, Würzburg, Germany.
11
Institute of Psychiatry Bari University Hospital, Bari, Italy.
12
Department of Basic Medical Science, Neuroscience and Sense Organs University of Bari, Bari, Italy.
13
Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
14
Division of Radiology and Nuclear Medicine, Section of Neuroradiology Oslo University Hospital, Oslo, Norway.
15
Psychosomatic and CL Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
16
Department of Psychiatry (UPK), University of Basel, Basel, Switzerland.
17
Department of Psychiatry, Psychosomatics and Psychotherapy University of Lübeck, Lübeck, Germany.
18
Institute of Psychiatry King's College, London, UK.
19
Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour Radboud University Medical Center, Nijmegen, The Netherlands.
20
Karakter Child and Adolescent Psychiatry University Centre, Nijmegen, The Netherlands.
21
Department of Neurology, Oslo University Hospital, Oslo, Norway.
22
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy University of Tübingen, Tübingen, Germany.
23
Center for Multimodal Imaging and Genetics, University of California at San Diego, La Jolla, CA, USA.
24
Department of Radiology, University of California, San Diego, La Jolla, CA, USA.
25
Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
26
Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
27
Division of Cognitive Neuroscience, University of Basel, Basel, Switzerland.
28
Transfaculty Research Platform Molecular and Cognitive Neurosciences University of Basel, Basel, Switzerland.
29
Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.
30
NORMENT, Department of Clinical Science, University of Bergen, Bergen, Norway.
31
Department of Psychology, University of Oslo, Oslo, Norway.
32
Sunnaas Rehabilitation Hospital HT, Nesodden, Norway.
33
Departments of Human Genetics and Psychiatry, Donders Institute for Brain, Cognition and Behaviour Radboud University Medical Center, Nijmegen, The Netherlands.
34
Department of Neuromedicine and Movement Science Norwegian, University of Science and Technology, Trondheim, Norway.
35
Department of Radiology and Nuclear Medicine St. Olavs Hospital, Trondheim, Norway.
36
Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
37
Clinical Neuropsychology section Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
38
Department of Cognitive Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
39
Department of Child and Adolescent Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
40
Center for Human Development, University of California, San Diego, USA.
41
Department of Cognitive Science, University of California, San Diego, USA.
42
Departments of Psychiatry and Radiology, University of California, San Diego, USA.
43
Faculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway.
44
Department of Clinical Psychology Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
45
Bernstein Center for Computational Neuroscience Heidelberg/Mannheim, Mannheim, Germany.
46
Department of Old Age Psychiatry and Psychotic Disorders Medical University of Lodz, Lodz, Poland.
47
Division of Molecular Psychiatry, Center of Mental Health, University of Würzburg, Würzburg, Germany.
48
Laboratory of Psychiatric Neurobiology, Institute of Molecular Medicine Sechenov First Moscow State Medical University, Moscow, Russia.
49
Department of Neuroscience, School for Mental Health and Neuroscience (MHeNS) Maastricht University, Maastricht, The Netherlands.
50
Department of Psychiatry, Warneford Hospital University of Oxford, Oxford, UK.
51
Department of Biomedicine, University of Bergen, Bergen, Norway.
52
Mohn Medical Imaging and Visualization Centre, Department of Radiology, Haukeland University Hospital, Bergen, Norway.
53
Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway.
54
Department of Research and Education, Oslo University Hospital, Oslo, Norway.
55
Institute of Gerontology and Geriatrics, University of Perugia, Perugia, Italy.
56
CatoSenteret Rehabilitation Center Son, Oslo, Norway.
57
Departments of Radiation Sciences and Integrative Medical Biology, Umeå Center for Functional Brain Imaging Umeå University, Umeå, Sweden.
58
Emma Children's Hospital, Amsterdam UMC University of Amsterdam and Vrije Universiteit Amsterdam, Emma Neuroscience Group, Department of Pediatrics, Amsterdam Reproduction & Development, Amsterdam, The Netherlands.
59
Division of Molecular Neuroscience University of Basel, Basel, Switzerland.
60
Life Sciences Training Facility, Department Biozentrum University of Basel, Basel, Switzerland.
61
Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway.
62
Norwegian National Advisory Unit on Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway.
63
Department of Neurology, Institute of Clinical Medicine University of Eastern Finland, Kuopio, Finland.
64
Neurocenter, Neurology Kuopio University Hospital, Kuopio, Finland.
65
Dr. E. Martens Research Group for Biological Psychiatry, Department of Medical Genetics Haukeland University Hospital, Bergen, Norway.
66
1st Department of Neurology Aristotle University of Thessaloniki, Thessaloniki, Greece.
67
UMR Inserm 1027, CHU Toulouse, UPS, Toulouse, France.
68
Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
69
Department of Neurobiology Care Sciences and Society, Karolinska Institute, Stockholm, Sweden.
70
District hospital Ansbach, Ansbach, Germany.
71
NORMENT, Division of Mental Health and Addiction Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway. l.t.westlye@psykologi.uio.no.
72
Department of Psychology, University of Oslo, Oslo, Norway. l.t.westlye@psykologi.uio.no.

Abstract

Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3-96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.

PMID:
31551603
DOI:
10.1038/s41593-019-0471-7

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