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RNA. 2019 Sep 23. pii: rna.065763.118. doi: 10.1261/rna.065763.118. [Epub ahead of print]

Genetic robustness of let-7 miRNA sequence-structure pairs.

Author information

1
University of Virginia, Biocomplexity Institute and Initiative.
2
University of Virginia, Biocomplexity Institute and Initiative duckcr@gmail.com.

Abstract

Genetic robustness, the preservation of evolved phenotypes against genotypic mutations, is one of the central concepts in evolution. In recent years a large body of work has focused on the origins, mechanisms, and consequences of robustness in a wide range of biological systems. In particular, research on ncRNAs studied the ability of sequences to maintain folded structures against single-point mutations. In these studies, the structure is merely a reference. However, recent work revealed evidence that structure itself contributes to the genetic robustness of ncRNAs. We follow this line of thought and consider sequence-structure pairs as the unit of evolution and introduce the spectrum of extended mutational robustness (EMR-spectrum) as a measurement of genetic robustness. Our analysis of the miRNA let-7 family captures key features of structure-modulated evolution and facilitates the study of robustness against multiple-point mutations.

KEYWORDS:

genetic robustness; let-7 miRNA; multiple-point mutation; sequence-structure pairs

PMID:
31548338
DOI:
10.1261/rna.065763.118

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