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J Heart Lung Transplant. 2019 Oct;38(10):1112-1115. doi: 10.1016/j.healun.2019.08.009. Epub 2019 Aug 10.

First report of a successful pediatric heart transplantation from donation after circulatory death with distant procurement using normothermic regional perfusion and cold storage.

Author information

1
Department of Cardiovascular Surgery, CHU Liege, Liege, Belgium. Electronic address: vtchanasato@chuliege.be.
2
Department of Anesthesiology and Intensive Care, CHU Liege, Liege, Belgium.
3
Department of Cardiac Surgery, The University Hospitals, Leuven, Belgium.
4
Department of Cardiology, The University Hospitals, Leuven, Belgium.
5
Department of Cardiology, CHU Liege, Liege, Belgium.
6
Department of Abdominal Surgery and Transplantation, CHU Liege, Liege, Belgium.
7
Department of Cardiovascular Surgery, CHU Liege, Liege, Belgium.

Abstract

Heart transplantation (HT) from donation after circulatory death (DCD) is a promising alternative to expand the heart donor pool. Cold storage can be used in a strategy to successfully retrieve and transplant DCD hearts after reconditioning using normothermic regional perfusion for distant procurement. Herein, we present the first report of a pediatric DCD heart reconditioned with normothermic regional perfusion, preserved using only cold storage while being transported to a neighboring center, and then successfully transplanted after nearly 2 hours of cold static storage. If supported by an appropriate trial, this finding could obviate the need to use expensive perfusion devices for short interhospital distances for DCD heart transportation and stimulate more centers across the world to embrace DCD HT.

KEYWORDS:

cold static storage; donation after circulatory death; heart transplantation; normothermic regional perfusion; organ donation

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