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Nutrients. 2019 Sep 12;11(9). pii: E2193. doi: 10.3390/nu11092193.

Sugar Beet Pectin Supplementation Did Not Alter Profiles of Fecal Microbiota and Exhaled Breath in Healthy Young Adults and Healthy Elderly.

Author information

1
Laboratory of Microbiology, Wageningen University & Research, 6708 WE Wageningen, The Netherlands. ran.an@wur.nl.
2
Division Gastroenterology-Hepatology, Department of Internal Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, 6202 AZ Maastricht, The Netherlands.
3
TI Food and Nutrition, 6700 AN Wageningen, The Netherlands.
4
Department of Pharmacology and Toxicology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, 6229 ER Maastricht, The Netherlands.
5
Laboratory of Microbiology, Wageningen University & Research, 6708 WE Wageningen, The Netherlands.
6
Division of Medical Biology, Department of Pathology and Medical Biology, University of Groningen and University Medical Centre Groningen, 9713 GZ Groningen, The Netherlands.
7
Laboratory of Food Chemistry, Wageningen University & Research, 6708 WG Wageningen, The Netherlands.
8
Food Innovation and Health, Centre for Healthy Eating and Food Innovation, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, 6200 MD Venlo, The Netherlands.

Abstract

Aging is accompanied with increased frailty and comorbidities, which is potentially associated with microbiome perturbations. Dietary fibers could contribute to healthy aging by beneficially impacting gut microbiota and metabolite profiles. We aimed to compare young adults with elderly and investigate the effect of pectin supplementation on fecal microbiota composition, short chain fatty acids (SCFAs), and exhaled volatile organic compounds (VOCs) while using a randomized, double-blind, placebo-controlled parallel design. Fifty-two young adults and 48 elderly consumed 15 g/day sugar beet pectin or maltodextrin for four weeks. Fecal and exhaled breath samples were collected before and after the intervention period. Fecal samples were used for microbiota profiling by 16S rRNA gene amplicon sequencing, and for analysis of SCFAs by gas chromatography (GC). Breath was used for VOC analysis by GC-tof-MS. Young adults and elderly showed similar fecal SCFA and exhaled VOC profiles. Additionally, fecal microbiota profiles were similar, with five genera significantly different in relative abundance. Pectin supplementation did not significantly alter fecal microbiota, SCFA or exhaled VOC profiles in elderly or young adults. In conclusion, aside from some minor differences in microbial composition, healthy elderly and young adults showed comparable fecal microbiota composition and activity, which were not altered by pectin supplementation.

KEYWORDS:

aging; dietary fiber; elderly; exhaled air; microbiota; pectin; young adults

PMID:
31547291
DOI:
10.3390/nu11092193
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