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Indian J Ophthalmol. 2019 Oct;67(10):1762-1765. doi: 10.4103/ijo.IJO_400_19.

Case report on two diabetic donor eyes with no retinopathy: Clinicopathological and molecular studies.

Author information

1
RS Mehta Jain Department of Biochemistry and Cell Biology, Vision Research Foundation, Chennai, India.
2
Department of Uveitis, Medical Research Foundation, Chennai, India.
3
Shri Bhagwan Mahavir Vitreoretinal Services, Medical Research Foundation, Chennai, India.
4
Aditya Jyot Eye Hospital, Mumbai, India.

Abstract

We were intrigued to analyze donor eyes of two individuals without retinopathy even after 40 years of type 2 diabetes mellitus. Targeted molecular factors associated with angiogenesis and the key antioxidant enzymes in retinal tissue were analyzed. Accordingly PEDF, Adiponectin and Paraoxonase 2 showed augmented mRNA expression in both the retina with no significant change in VEGF expression. Vitreous showed increased PEDF protein in donor 1 and Adiponectin in donor 2 with no change in VEGF protein. This study highlights the profile of specific molecular factors that contribute to the non-development of diabetic retinopathy changes in these individuals.

KEYWORDS:

Adiponectin and paraoxonase; PEDF; VEGF; diabetic retinopathy

PMID:
31546558
DOI:
10.4103/ijo.IJO_400_19
Free PMC Article

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