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Biomed Pharmacother. 2019 Oct;118:109362. doi: 10.1016/j.biopha.2019.109362. Epub 2019 Aug 24.

Sodium tanshinone IIA sulfonate: A review of pharmacological activity and pharmacokinetics.

Author information

1
Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China; State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macao, China. Electronic address: biozzy@126.com.
2
Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Cardiac Rehabilitation Center of Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address: witoy17@163.com.
3
Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address: 601729768@qq.com.
4
Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address: heal7374@163.com.
5
Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Cardiac Rehabilitation Center of Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address: dr_tang@163.com.

Abstract

Sodium tanshinone IIA sulfonate (STS) is a water-soluble derivate of tanshinone IIA (Tan IIA) which is an active lipophilic constitute of Chinese Materia Medica Salvia miltiorrhiza Bge. (Danshen). STS presents multiple pharmacological activities, including anti-oxidant, anti-inflammation and anti-apoptosis, and has been approved for treatment of cardiovascular diseases by China State Food and Drug Administration (CFDA). In this review, we comprehensively summarized the pharmacological activities and pharmacokinetics of STS, which could support the further application and development of STS. In the recent decades, numerous experimental and clinical studies have been conducted to investigate the potential treatment effects of STS in various diseases, such as heart diseases, brain diseases, pulmonary diseases, cancers, sepsis and so on. The underlying mechanisms were most related to anti-oxidative and anti-inflammatory effects of STS via regulating various transcription factors, such as NF-κB, Nrf2, Stat1/3, Smad2/3, Hif-1α and β-catenin. Iron channels, including Ca2+, K+ and Cl- channels, were also the important targets of STS. Additionally, we emphasized the differences between STS and Tan IIA despite the interchangeable use of Tan IIA and STS in many previous studies. It is promising to improve the efficacy and reduce side effects of chemotherapeutic drug by the combination use of STS in canner treatment. The application of STS in pregnancy needs to be seriously considered. Moreover, the drug-drug interactions between STS and other drugs needs to be further studied as well as the complications of STS.

KEYWORDS:

Apoptosis; Cardiovascular disease; Inflammation; Iron channel; Neoplasms; Oxidative stress; Sodium tanshinone IIA sulfonate; Traditional Chinese medicine; Transcription factor

PMID:
31545252
DOI:
10.1016/j.biopha.2019.109362
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