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Twin Res Hum Genet. 2019 Sep 23:1-8. doi: 10.1017/thg.2019.76. [Epub ahead of print]

IGEMS: The Consortium on Interplay of Genes and Environment Across Multiple Studies - An Update.

Author information

1
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
2
Center for Economic and Social Research, University of Southern California, Los Angeles, CA, USA.
3
Department of Psychology, Indiana University Southeast, New Albany, IN, USA.
4
Office of Military and Veterans Health, Health and Medicine Division, The National Academies of Sciences, Engineering, and Medicine, Washington, DC, USA.
5
Institute of Gerontology and Aging Research Network - Jönköping (ARN-J), School of Health and Welfare, Jönköping University, Jönköping, Sweden.
6
Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
7
Department of Public Health, Faculty of Medicine & Institute for Molecular Medicine FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.
8
Research and Evaluation, American Institutes for Research, Washington, DC, USA.
9
Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
10
Department of Epidemiology, Biostatistics and Biodemography, University of Southern Denmark, Odense, Denmark.
11
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
12
Department of Psychology, Penn State University, University Park, PA, USA.
13
The Danish Twin Registry, University of Southern Denmark, Odense C, Denmark.
14
Department of Psychology, University of Southern California, Los Angeles, CA, USA.
15
Department of Psychology, University of California - Riverside, Riverside, CA, USA.
16
Centre for Healthy Brain Ageing (CHeBA), University of New South Wales, Sydney, New South Wales, Australia.
17
Department of Psychology, Wayne State University, Detroit, MI, USA.

Abstract

The Interplay of Genes and Environment across Multiple Studies (IGEMS) is a consortium of 18 twin studies from 5 different countries (Sweden, Denmark, Finland, United States, and Australia) established to explore the nature of gene-environment (GE) interplay in functioning across the adult lifespan. Fifteen of the studies are longitudinal, with follow-up as long as 59 years after baseline. The combined data from over 76,000 participants aged 14-103 at intake (including over 10,000 monozygotic and over 17,000 dizygotic twin pairs) support two primary research emphases: (1) investigation of models of GE interplay of early life adversity, and social factors at micro and macro environmental levels and with diverse outcomes, including mortality, physical functioning and psychological functioning; and (2) improved understanding of risk and protective factors for dementia by incorporating unmeasured and measured genetic factors with a wide range of exposures measured in young adulthood, midlife and later life.

KEYWORDS:

Dementia; early life adversity; gene–environment interplay; health; socioeconomic status

PMID:
31544729
DOI:
10.1017/thg.2019.76

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