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J Indian Soc Periodontol. 2019 Sep-Oct;23(5):461-468. doi: 10.4103/jisp.jisp_700_18.

Evaluation of a curcumin-containing mucoadhesive film for periodontal postsurgical pain control.

Author information

1
Department of Periodontology, JSS Dental College and Hospital, JSSAHER, Mysore, Karnataka, India.
2
Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Research, Mysore, Karnataka, India.

Abstract

Background:

Management of pain and discomfort is important to make the postoperative period as pleasant as possible. Nonsteroidal anti-inflammatory drugs are traditionally prescribed; however, they are associated with numerous side effects. As a result, nutraceuticals such as curcumin are widely used for its well-known safety and medicinal values. Hence, the aim of this study is to evaluate the efficacy of a curcumin mucoadhesive film for postsurgical pain control.

Materials and Methods:

This was a split-mouth study, consisting of 15 systemically healthy patients with 30 sites, who were randomly allocated into test (curcumin mucoadhesive film) and control (placebo mucoadhesive film) groups using coin toss method. A questionnaire was given to patients to evaluate the postoperative pain and swelling and the number of rescue medications taken. Statistical analyses used were Friedman test, Wilcoxon signed-rank test, and McNemar's test.

Results:

No adverse effects were reported and healing was uneventful in all patients. The Numerical rating scale pain score showed significantly lesser pain at 1, 2, 3, 4, 5, and 24 h in the test group. Significantly more number of analgesics was consumed in total in the control group than that in the test group.

Conclusion:

Within the limitations of this study, it may be concluded that curcumin mucoadhesive film showed promising results in reducing postoperative pain and swelling over a period of 1 week, hence showing its analgesic effect after periodontal surgeries.

KEYWORDS:

Analgesic; anti-inflammatory; chronic periodontitis; curcumin; mucoadhesive film; numerical rating scale; pain assessment; postoperative pain; swelling

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