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J Indian Soc Periodontol. 2019 Sep-Oct;23(5):461-468. doi: 10.4103/jisp.jisp_700_18.

Evaluation of a curcumin-containing mucoadhesive film for periodontal postsurgical pain control.

Author information

Department of Periodontology, JSS Dental College and Hospital, JSSAHER, Mysore, Karnataka, India.
Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Research, Mysore, Karnataka, India.



Management of pain and discomfort is important to make the postoperative period as pleasant as possible. Nonsteroidal anti-inflammatory drugs are traditionally prescribed; however, they are associated with numerous side effects. As a result, nutraceuticals such as curcumin are widely used for its well-known safety and medicinal values. Hence, the aim of this study is to evaluate the efficacy of a curcumin mucoadhesive film for postsurgical pain control.

Materials and Methods:

This was a split-mouth study, consisting of 15 systemically healthy patients with 30 sites, who were randomly allocated into test (curcumin mucoadhesive film) and control (placebo mucoadhesive film) groups using coin toss method. A questionnaire was given to patients to evaluate the postoperative pain and swelling and the number of rescue medications taken. Statistical analyses used were Friedman test, Wilcoxon signed-rank test, and McNemar's test.


No adverse effects were reported and healing was uneventful in all patients. The Numerical rating scale pain score showed significantly lesser pain at 1, 2, 3, 4, 5, and 24 h in the test group. Significantly more number of analgesics was consumed in total in the control group than that in the test group.


Within the limitations of this study, it may be concluded that curcumin mucoadhesive film showed promising results in reducing postoperative pain and swelling over a period of 1 week, hence showing its analgesic effect after periodontal surgeries.


Analgesic; anti-inflammatory; chronic periodontitis; curcumin; mucoadhesive film; numerical rating scale; pain assessment; postoperative pain; swelling

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