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J Indian Soc Periodontol. 2019 Sep-Oct;23(5):424-429. doi: 10.4103/jisp.jisp_217_19.

Higher interleukin-33 levels in aggressive periodontitis cases.

Author information

Department of Periodontology, DSCDS, Bengaluru, Karnataka, India.
Department of Periodontology, Government Dental College and Research Institute, Bengaluru, Karnataka, India.
Department of Periodontology, The Oxford Dental College, Bengaluru, Karnataka, India.
Department of Psychiatry, National Institute of Mental Health and Neuro Sciences, Bengaluru, Karnataka, India.



Interleukin-33 (IL-33) is a novel alarmin that warns immune cells of tissue destruction in injury or infection.


This study is aimed at analyzing and correlating the concentration of IL-33 in the gingival crevicular fluid (GCF) and plasma of healthy subjects and chronic and aggressive periodontitis patients with intronic variant single nucleotide polymorphisms (SNPs), rs1157505 (C/G) and rs7044343 (C/T) in the IL-33 gene.

Settings and Design:

This is a cross-sectional, biochemical, genetic study.

Materials and Methods:

Ninety subjects were divided into Group H: subjects with healthy periodontium, Group CP: chronic periodontitis patients, and Group GAgP: generalized aggressive periodontitis patients, based on clinical parameters of periodontal inflammation. IL-33 concentration in GCF, as well as plasma, was quantified using enzyme-linked immunosorbent assay. The SNPs rs1157505 and rs7044343 were analyzed using polymerase chain reaction-restriction fragment length polymorphism.


A significant difference was found in IL-33 concentration in GCF and plasma between the three groups. GG genotype of IL-33 SNP rs1157505 was associated with the highest GCF and plasma IL-33 concentration and was significantly more in GAgP than healthy or CP groups. IL-33 SNP rs7044343 did not show any such association. All GAgP patients had the highest GCF and plasma concentration of IL-33.


IL-33 may be a potential inflammatory marker of periodontitis. GG genotype of SNP rs1157505 may be associated with GAgP.


Aggressive periodontitis; chronic periodontitis; genetic polymorphism; gingival crevicular fluid; interleukin

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