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Niger Med J. 2019 May-Jun;60(3):149-155. doi: 10.4103/nmj.NMJ_74_19.

The Impact of 6-month Micronutrient Supplementation on Viral, Immunological, and Mental Health Profile of a Cohort of Highly Active Antiretroviral Therapy-Naive HIV-Positive Patients in Northern Nigeria.

Author information

1
Department of Psychiatry, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria.
2
Department of Clinical Services, Medical Services Unit, Federal Neuropsychiatric Hospital, Kaduna, Kaduna State, Nigeria.
3
Department of Psychiatry, College of Health Sciences, Bingham University, Jos, Plateau State, Nigeria.
4
Department of Medicine, Ahmadu Bello University, Zaria, Nigeria.
5
Department of Internal Medicine, Kaduna State University, Kaduna, Kaduna State, Nigeria.

Abstract

Background:

HIV is a chronic disease with inflammatory reactions involving numerous elements of the immune system, resulting in an increased risk for other physical and psychiatric morbidities. Micronutrients, some of which possess anti-inflammatory properties, may help prevent the development of psychological disorders such as anxiety and depression in people living with HIV disease.

Objectives:

This study examined the profile of viral load, CD4 cell count, C-reactive protein, anxiety, and depression among highly active antiretroviral therapy (HAART)-naive HIV-positive patients receiving micronutrient supplementation over a 6-month period.

Materials and Methods:

A total of ninety HAART-naïve HIV-infected patients completed the Hospital Anxiety Depression Scale. Their blood samples were taken for serum viral load, CD4 cell count, and C-reactive protein at baseline. They all received a micronutrient supplement for 6 months, and 68 participants who remained in treatment at 6 months were reassessed with the same parameters.

Results:

After 6 months of micronutrient supplementation, the participants were found to have statistically significantly lower mean scores on the anxiety (t-test = 2.970, P = 0.003) and depression (t-test = 3.843, P = 0.001) subscales. They also had statistically significantly lower median CD4 cell count (P = 0.00) and C-reactive protein serum measures (P = 0.04). The median viral load decreased although the difference was not statistically significant.

Conclusion:

Micronutrient supplementation may reduce inflammatory reactions, anxiety, and depression in HAART-naive HIV-infected persons.

KEYWORDS:

Anxiety; CD4 count; HIV; Nigeria; depression; highly active antiretroviral therapy-naive; micronutrients; viral load

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