Send to

Choose Destination
Niger Med J. 2019 May-Jun;60(3):149-155. doi: 10.4103/nmj.NMJ_74_19.

The Impact of 6-month Micronutrient Supplementation on Viral, Immunological, and Mental Health Profile of a Cohort of Highly Active Antiretroviral Therapy-Naive HIV-Positive Patients in Northern Nigeria.

Author information

Department of Psychiatry, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria.
Department of Clinical Services, Medical Services Unit, Federal Neuropsychiatric Hospital, Kaduna, Kaduna State, Nigeria.
Department of Psychiatry, College of Health Sciences, Bingham University, Jos, Plateau State, Nigeria.
Department of Medicine, Ahmadu Bello University, Zaria, Nigeria.
Department of Internal Medicine, Kaduna State University, Kaduna, Kaduna State, Nigeria.



HIV is a chronic disease with inflammatory reactions involving numerous elements of the immune system, resulting in an increased risk for other physical and psychiatric morbidities. Micronutrients, some of which possess anti-inflammatory properties, may help prevent the development of psychological disorders such as anxiety and depression in people living with HIV disease.


This study examined the profile of viral load, CD4 cell count, C-reactive protein, anxiety, and depression among highly active antiretroviral therapy (HAART)-naive HIV-positive patients receiving micronutrient supplementation over a 6-month period.

Materials and Methods:

A total of ninety HAART-naïve HIV-infected patients completed the Hospital Anxiety Depression Scale. Their blood samples were taken for serum viral load, CD4 cell count, and C-reactive protein at baseline. They all received a micronutrient supplement for 6 months, and 68 participants who remained in treatment at 6 months were reassessed with the same parameters.


After 6 months of micronutrient supplementation, the participants were found to have statistically significantly lower mean scores on the anxiety (t-test = 2.970, P = 0.003) and depression (t-test = 3.843, P = 0.001) subscales. They also had statistically significantly lower median CD4 cell count (P = 0.00) and C-reactive protein serum measures (P = 0.04). The median viral load decreased although the difference was not statistically significant.


Micronutrient supplementation may reduce inflammatory reactions, anxiety, and depression in HAART-naive HIV-infected persons.


Anxiety; CD4 count; HIV; Nigeria; depression; highly active antiretroviral therapy-naive; micronutrients; viral load

Supplemental Content

Full text links

Icon for Medknow Publications and Media Pvt Ltd Icon for PubMed Central
Loading ...
Support Center