Pulmonary embolism occurring early after major trauma

BMJ Case Rep. 2019 Sep 20;12(9):e228783. doi: 10.1136/bcr-2018-228783.

Abstract

Pulmonary embolism (PE) secondary to trauma is the third most common cause of death in trauma patients who have survived 24 hours following injury. We describe a case of PE diagnosed within 3 hours of a major trauma in a previously well adolescent female. The early occurrence of PE in this case is at odds with what is generally reported (3-5 days) after major trauma. General consensus is that patients who suffer major trauma move from an initial hypocoaguable state, with increased risk of bleeding, to normocoagulable or hypercoaguable state, with a subsequent increased risk of venothromboembolism. However, Sumislawski et al recently demonstrated that a marginally greater proportion of trauma patients were in fact hypercoaguable rather than hypocoaguable on arrival to hospital and that trauma-induced coagulopathy tended to resolve within 24 hours; such data cause us to re-evaluate when to commence thromboprophylaxis for major trauma patients.

Keywords: anaesthesia; orthopaedic and trauma surgery; pulmonary embolism; radiology; trauma.

Publication types

  • Case Reports

MeSH terms

  • Accidents, Traffic
  • Adolescent
  • Amputation, Surgical
  • Anticoagulants / therapeutic use*
  • Blood Transfusion
  • Clinical Protocols
  • Computed Tomography Angiography
  • Female
  • Heparin / therapeutic use*
  • Humans
  • Leg Injuries / complications
  • Leg Injuries / physiopathology*
  • Leg Injuries / therapy
  • Pulmonary Embolism / diagnostic imaging*
  • Pulmonary Embolism / etiology
  • Pulmonary Embolism / therapy
  • Treatment Outcome
  • Venous Thromboembolism / diagnostic imaging*

Substances

  • Anticoagulants
  • Heparin