The Dark Side of Estrogen Stops Translation to Induce Apoptosis

Heather M Lamb; J Marie Hardwick

doi:10.1016/j.molcel.2019.08.022

The Dark Side of Estrogen Stops Translation to Induce Apoptosis

Mol Cell. 2019 Sep 19;75(6):1087-1089. doi: 10.1016/j.molcel.2019.08.022.

Authors

Heather M Lamb¹, J Marie Hardwick²

Affiliations

¹ Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA.
² Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA. Electronic address: hardwick@jhu.edu.

PMID: 31539505
DOI: 10.1016/j.molcel.2019.08.022

Abstract

The role of hormones in triggering cell death has been controversial. In this issue of Molecular Cell, Li et al. (2019) have defined a molecular pathway where an unexpected estrogen receptor, phosphodiesterase 3A, allows its partner Schlafen-12 to inhibit survival pathways, ultimately leading to apoptosis.

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MeSH terms

Apoptosis*
Estrogens*
Receptors, Estrogen

Substances

Estrogens
Receptors, Estrogen

Abstract

Publication types

MeSH terms

Substances

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