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Appl Physiol Nutr Metab. 2019 Sep 20. doi: 10.1139/apnm-2019-0267. [Epub ahead of print]

ARONIA JUICE CONSUMPTION PRIOR TO HALF-MARATHON RACE CAN ACUTELY AFFECT PLATELET ACTIVATION IN RECREATIONAL RUNNERS.

Author information

1
Institute for Medical Research, Centre of Research Excellence in Nutrition and Metabolism , Tadeuša Košćuškog 1 , Belgrade, Serbia , 11000 ; wolfdif@yahoo.com.
2
Institute for medical research, Belgrade, Serbia ; kaya_7b@hotmail.com.
3
Institute for Medical Research, Belgrade, Serbia ; irenakrga@yahoo.com.
4
Institute for medical research, Belgrade, Serbia ; zekovicmilica@gmail.com.
5
Institute for Medical Research, Centre of Research Excellence in Nutrition and Metabolism , Tadeuša Košćuška 1 , Belgrade , Belgrade, Serbia , 11 158 ; ivanasarac@yahoo.com.
6
Institute for Medical Research, Centre of Research Excellence in Nutrition and Metabolism, Belgrade, Serbia ; mglibetic@gmail.com.
7
Institute for Medical Research, Centre of Research Excellence in Nutrition and Metabolism , Dr Subotica 4 , Belgrade, Serbia , 11000 ; nevenakardum@gmail.com.

Abstract

Long-distance running, especially in non-professional runners, can increase cardiac arrest risk by enhancing platelet activation and aggregation. Polyphenols can exert cardioprotective effects by positively influencing platelet function. This study aimed to examine the acute effects of polyphenol-rich aronia juice consumption, before simulation of a half-marathon race, on platelet activation and aggregation with leukocytes in recreational runners. In this acute cross-over study, 10 healthy male runners (age 30.8 ± 2.3years) consumed breakfast with 200ml of aronia juice or 200ml of placebo. They warmed-up and ran a simulated half-marathon race (21.1km). Blood was collected at baseline, 15min, 1h and 24h after the run. All variables were analysed with 4(Time)x2(Group) analysis of variance with repeated measures on both factors. Results revealed a significant effect of Group on platelet activation parameters: P-selectin and GPIIb-IIIa expressions significantly decreased in aronia compared with the placebo arm (F(1,9)=10.282, p=0.011 and F(1,9)=7.860, p=0.021, respectively). The effect of Time was significant on both platelet aggregation markers: platelet-monocyte and platelet-neutrophil aggregates were significantly lower after the race (F(3,7)=4.227, p=0.014 and F(3,7)=70.065, p=0.000, respectively), with changes more pronounced in the later. All effects remained when platelets were exposed to an agonist. These results suggest that aronia consumption could counteract the half-marathon race-induced changes in platelet function. •Aronia juice consumption significantly decreased the expression of platelet activation markers, but didn't affect platelet aggregation. •The race itself did significantly reduced platelet-neutrophil aggregation. •Aronia juice may serve as a supplement beverage for recreational runners, to alleviate enhanced platelet reactivity caused by prolonged running.

PMID:
31539487
DOI:
10.1139/apnm-2019-0267

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