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Doc Ophthalmol. 2019 Sep 19. doi: 10.1007/s10633-019-09720-8. [Epub ahead of print]

Identification of clusters in multifocal electrophysiology recordings to maximize discriminant capacity (patients vs. control subjects).

Author information

1
Biomedical Engineering Group, Electronics Department, University of Alcalá, Alcalá de Henares, Spain.
2
School of Physics, University of Melbourne, Melbourne, VIC, 3010, Australia.
3
Ophthalmology Department, Miguel Servet University Hospital, Zaragoza, Spain.
4
Aragon Institute for Health Research (IIS Aragon), Miguel Servet Ophthalmology Innovation and Research Group (GIMSO), University of Zaragoza, 50009, Zaragoza, Spain.
5
12 de Octubre University Hospital Research Institute (i + 12), Madrid, Spain.
6
Faculty of Medicine, Complutense University of Madrid, Madrid, Spain.
7
Ophthalmology Department, Miguel Servet University Hospital, Zaragoza, Spain. mariajesusrodrigo@hotmail.es.
8
Aragon Institute for Health Research (IIS Aragon), Miguel Servet Ophthalmology Innovation and Research Group (GIMSO), University of Zaragoza, 50009, Zaragoza, Spain. mariajesusrodrigo@hotmail.es.
9
RETICS: Thematic Networks for Co-operative Research in Health for Ocular Diseases, Barcelona, Spain.

Abstract

PURPOSE:

To propose a new method of identifying clusters in multifocal electrophysiology (multifocal electroretinogram: mfERG; multifocal visual-evoked potential: mfVEP) that conserve the maximum capacity to discriminate between patients and control subjects.

METHODS:

The theoretical framework proposed creates arbitrary N-size clusters of sectors. The capacity to discriminate between patients and control subjects is assessed by analysing the area under the receiver operator characteristic curve (AUC). As proof of concept, the method is validated using mfERG recordings taken from both eyes of control subjects (n = 6) and from patients with multiple sclerosis (n = 15).

RESULTS:

Considering the amplitude of wave P1 as the analysis parameter, the maximum value of AUC = 0.7042 is obtained with N = 9 sectors. Taking into account the AUC of the amplitudes and latencies of waves N1 and P1, the maximum value of the AUC = 0.6917 with N = 8 clustered sectors. The greatest discriminant capacity is obtained by analysing the latency of wave P1: AUC = 0.8854 with a cluster of N = 12 sectors.

CONCLUSION:

This paper demonstrates the effectiveness of a method able to determine the arbitrary clustering of multifocal responses that possesses the greatest capacity to discriminate between control subjects and patients when applied to the visual field of mfERG or mfVEP recordings. The method may prove helpful in diagnosing any disease that is identifiable in patients' mfERG or mfVEP recordings and is extensible to other clinical tests, such as optical coherence tomography.

KEYWORDS:

Multifocal electroretinogram; Multifocal visual-evoked potential; Multiple sclerosis; Visual field

PMID:
31538293
DOI:
10.1007/s10633-019-09720-8

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