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Aust N Z J Public Health. 2020 Feb;44(1):53-58. doi: 10.1111/1753-6405.12935. Epub 2019 Sep 18.

Epidemiology of sepsis in cancer patients in Victoria, Australia: a population-based study using linked data.

Author information

1
Cancer Epidemiology Division, Cancer Council Victoria.
2
Cancer Strategy & Development, Department of Health and Human Services, Victoria.
3
Retired.
4
Information Management and Standards, Victorian Agency for Health Information, Victoria.
5
Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Victoria.

Abstract

OBJECTIVE:

To determine the clinical characteristics, outcomes and longitudinal trends of sepsis occurring in cancer patients.

METHOD:

Retrospective study using statewide Victorian Cancer Registry data linked to various administrative datasets.

RESULTS:

Among 215,763 incident cancer patients, incidence of sepsis within one year of cancer diagnosis was estimated at 6.4%. The incidence of sepsis was higher in men, younger patients, patients diagnosed with haematological malignancies and those with de novo metastatic disease. Of the 13,316 patients with a first admission with sepsis, 55% had one or more organ failures, 29% required care within an intensive care unit and 13% required mechanical ventilation. Treatments associated with the highest sepsis incidence were stem cell/bone marrow transplant (33%), major surgery (4.4%), chemotherapy (1.1%) and radical radiotherapy (0.6%). The incidence of sepsis with organ failure increased between 2008 and 2015, while 90-day mortality decreased.

CONCLUSIONS:

Sepsis in patients with cancer has high mortality and occurs most frequently in the first year after cancer diagnosis. Implications for public health: The number of cancer patients diagnosed with sepsis is expected to increase, causing a substantial burden on patients and the healthcare system.

KEYWORDS:

cancer; epidemiology; sepsis

PMID:
31535416
DOI:
10.1111/1753-6405.12935
[Indexed for MEDLINE]

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