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Aging Clin Exp Res. 2019 Sep 18. doi: 10.1007/s40520-019-01352-x. [Epub ahead of print]

Bone and skeletal muscle changes in oldest-old women: the role of physical inactivity.

Author information

1
Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
2
Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy. chiara.milanese@univr.it.
3
Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA.

Abstract

BACKGROUND:

Alterations in bone and muscle parameters related to advanced aging and physical inactivity have never been investigated in oldest-old women.

AIMS:

To investigate the impact of physical inactivity on bone mineral density (BMD) and body composition at the systemic and regional levels in oldest-old (> 75 years old) women. We hypothesized that, further to aging, alterations in bone and body composition parameters are exacerbated in the locomotor limbs that have experienced physical inactivity.

METHODS:

Whole-body and regional (lower limbs and trunk) BMD and fat-free soft tissue mass (FFSTM) were measured by means of dual-energy X-ray absorptiometry in 11 oldest-old wheelchair-bound women (OIW), 11 oldest-old mobile women (OMW), and 11 young healthy women (YW), all matched for weight (± 10 kg), height (± 10 cm).

RESULTS:

Whole-body BMD was reduced by 15% from YW to OMW and 10% from OMW to OIW. Whole-body FFSTM was also reduced from YW to OIW (- 13%). Lower limb BMD was progressively reduced among YW, OMW and OIW (- 23%). Similarly, lower limb FFSTM was reduced among YW (12,816 ± 1797 g), OMW (11,999 ± 1512 g) and OIW (10,037 ± 1489 g). Trunk BMD was progressively reduced among YW, OMW and OIW (- 19%), while FFSTM was similar among the three groups ~ 19801 g.

CONCLUSIONS:

The results of the present study suggest that the alterations in bone and body composition parameters are exacerbated in the physical inactive oldest-old. These negative effects of physical inactivity are not confined to the locomotor limbs, and a systemic decline of bone and muscle parameters are likely associated with the physical inactivity.

KEYWORDS:

Oldest-old; Osteoporosis; Physical inactivity; Sarcopenia

PMID:
31535334
DOI:
10.1007/s40520-019-01352-x

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