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Intern Med. 2019 Sep 18. doi: 10.2169/internalmedicine.3218-19. [Epub ahead of print]

Successful Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome with Chronic Febricula Using the Traditional Japanese Medicine Shosaikoto.

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Department of Kampo Medicine, National Hospital Organization Yonezawa National Hospital, Japan.
Department of Education and Support for Regional Medicine, Department of Kampo Medicine, Tohoku University Hospital, Japan.
Department of Respiratory Medicine, Fujiwara Memorial Hospital, Japan.


We herein report the case of a 14-year-old girl who had been experiencing chronic fatigue, febricula, and social withdrawal for 20 months. No notable abnormalities were identified during routine checkups at a general pediatric hospital; symptomatic treatments did not affect her condition. She was diagnosed with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Based on the concepts of Japanese traditional medicine, she was administered shosaikoto-based treatment. After several weeks of treatment, all of the symptoms had been dramatically alleviated, consequently resolving the issue of non-attendance at school. Shosaikoto-based medication may be a therapeutic option for treating ME/CFS in patients presenting with chronic febricula.


Kampo medicine; chronic febricula; late yang stage pattern; myalgic encephalomyelitis/chronic fatigue syndrome; neuroinflammation; shosaikoto

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