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Microorganisms. 2019 Sep 17;7(9). pii: E359. doi: 10.3390/microorganisms7090359.

MicroRNAs in Ocular Infection.

Author information

1
Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University, School of Medicine, Detroit, MI 48201, USA. sxu@med.wayne.edu.
2
Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University, School of Medicine, Detroit, MI 48201, USA. lhazlett@med.wayne.edu.

Abstract

MicroRNAs (miRNAs) are small, non-coding, regulatory RNA molecules and constitute a newly recognized, important layer of gene-expression regulation at post-transcriptional levels. miRNAs quantitatively fine tune the expression of their downstream genes in a cell type- and developmental stage-specific fashion. miRNAs have been proven to play important roles in the normal development and function as well as in the pathogenesis of diseases in all tissues and organ systems. miRNAs have emerged as new therapeutic targets and biomarkers for treatment and diagnosis of various diseases. Although miRNA research in ocular infection remains in its early stages, a handful of pioneering studies have provided insight into the roles of miRNAs in the pathogenesis of parasitic, fungal, bacterial, and viral ocular infections. Here, we review the current status of research in miRNAs in several major ocular infectious diseases. We predict that the field of miRNAs in ocular infection will greatly expand with the discovery of novel miRNA-involved molecular mechanisms that will inform development of new therapies and identify novel diagnostic biomarkers.

KEYWORDS:

bacterial keratitis; fungal keratitis; herpes simplex stromal keratitis (HSK); microRNAs (miRNAs), ocular infection; pseudomonas aeruginosa (PA); river blindness; trachoma

PMID:
31533211
DOI:
10.3390/microorganisms7090359
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