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Anal Chem. 2019 Oct 15;91(20):13285-13289. doi: 10.1021/acs.analchem.9b04034. Epub 2019 Sep 26.

Fabrication of a Tyrosine-Responsive Liquid Quantum Dots Based Biosensor through Host-Guest Chemistry.

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School of Chemistry and Chemical Engineering , Hubei Polytechnic University , Huangshi 435003 , China.
Key Laboratory of Pesticides and Chemical Biology, Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, Center of Chemical Biology, College of Chemistry , Central China Normal University , Wuhan 430079 , China.
Research Center for Analytical Sciences, Department of Chemistry, College of Sciences , Northeastern University , Shenyang 110819 , China.
CAS Key Laboratory of Nano-Bio Interface, Suzhou Institute of Nano-Tech and Nano-Bionics , Chinese Academy of Sciences , Suzhou 215123 , China.


Design and fabrication of smart liquid quantum dots (LQDs) with high biomolecule selectivity and specificity remains a challenge. Herein, a multifunctional calix[4]arene derivative (PCAD) was rationally designed and applied to fabricate a Tyr-responsive CdSe-LQD system through host-guest chemistry. Such a biosensor displays an outstanding fluorescence/macroscopic response for Tyr and reversible fluidic features due to the hydrogen interaction between the PCAD of CdSe-LQDs and Tyr. These excellent results highlighted CdSe-LQDs as a promising platform for biological molecule recognition and separation in the future.

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