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Med Sci (Paris). 2019 Aug-Sep;35(8-9):682-688. doi: 10.1051/medsci/2019132. Epub 2019 Sep 18.

[Elemental imaging using laser-induced breakdown spectroscopy: latest medical applications].

[Article in French; Abstract available in French from the publisher]

Author information

1
Institut Lumière Matière, CNRS UMR 5306, Lyon 1 University, Villeurbanne, France. - Institute for Advanced Biosciences (IAB), Team « Cancer Targets and Experimental Therapeutics », Inserm U1209, CNRS UMR5309, Grenoble Alpes University, allée des Alpes, 38700 Grenoble, France.
2
Institute for Advanced Biosciences (IAB), Team « Cancer Targets and Experimental Therapeutics », Inserm U1209, CNRS UMR5309, Grenoble Alpes University, allée des Alpes, 38700 Grenoble, France.
3
Institut Lumière Matière, CNRS UMR 5306, Lyon 1 University, Villeurbanne, France.
4
Institute for Advanced Biosciences (IAB), Team « Cancer Targets and Experimental Therapeutics », Inserm U1209, CNRS UMR5309, Grenoble Alpes University, allée des Alpes, 38700 Grenoble, France. - Clinical Cancer Laboratory, Biochemistry Department, Grenoble Alpes University Hospital, Grenoble, France.

Abstract

in English, French

Multi-elemental imaging of soft tissues using Laser-induced breakdown spectroscopy, also known as LIBS, allows for the direct visualization of the distribution of endogenous or exogenous elements within tissues. LIBS was used to image the kinetics of metal nanoparticles in elimination organs, but also the physiological distribution of biological elements in situ and the topography of chemicals or metals in exposed human tissues. Based on our experience and recent literature in the field of imaging the elemental content of animal and human specimens, this review describes the principle and characteristics of the instrument, technical considerations for setting up experiments with LIBS, its advantages, limitations and possibilities for pre-clinical and medical applications.

PMID:
31532381
DOI:
10.1051/medsci/2019132

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