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Med Sci (Paris). 2019 Aug-Sep;35(8-9):667-673. doi: 10.1051/medsci/2019130. Epub 2019 Sep 18.

[Importance of cellular microRNAs in the regulation of viral infections].

[Article in French; Abstract available in French from the publisher]

Author information

1
Architecture et Réactivité de l'ARN, Université de Strasbourg, Institut de Biologie Moléculaire et Cellulaire du CNRS, 15, rue René Descartes, 67084 Strasbourg, France.

Abstract

in English, French

Viruses are obligatory intracellular parasites that rely on a wide range of cellular factors to successfully accomplish their infectious cycle. Among those, micro (mi)RNAs have recently emerged as important modulators of viral infections. These small regulatory molecules act as repressors of gene expression. During infection, miRNAs can function by targeting either cellular or viral RNAs. In this review, we will recapitulate what has been reported to date on this interplay between cellular miRNAs and viruses and the effect on the infection. Furthermore, we will briefly discuss the possibilities of interfering with the infection through the modulation of this pathway to develop novel antiviral therapies.

PMID:
31532379
DOI:
10.1051/medsci/2019130

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