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Med Sci (Paris). 2019 Aug-Sep;35(8-9):635-642. doi: 10.1051/medsci/2019129. Epub 2019 Sep 18.

[LAP (LC3-associated phagocytosis): phagocytosis or autophagy?]

[Article in French; Abstract available in French from the publisher]

Author information

1
Institut de recherche en infectiologie de Montpellier (IRIM), Université de Montpellier, CNRS, 1919, route de Mende, 34293 Montpellier, France.
2
Institut de pharmacologie et de biologie structurale (IPBS), Université de Toulouse, CNRS, UPS, 205, route de Narbonne, 31400 Toulouse, France.

Abstract

in English, French

Phagocytosis and macroautophagy, named here autophagy, are two essential mechanisms of lysosomal degradation of diverse cargos into membrane structures. Both mechanisms are involved in immune regulation and cell survival. However, phagocytosis triggers degradation of extracellular material whereas autophagy engulfs only cytoplasmic elements. Furthermore, activation and maturation of these two processes are different. LAP (LC3-associated phagocytosis) is a form of phagocytosis that uses components of the autophagy pathway. It can eliminate (i) pathogens, (ii) immune complexes, (iii) threatening neighbouring cells, dead or alive, and (iv) cell debris, such as POS (photoreceptor outer segment) and the midbody released at the end of mitosis. Cells have thus optimized their means of elimination of dangerous components by sharing some fundamental elements coming from the two main lysosomal degradation pathways.

PMID:
31532375
DOI:
10.1051/medsci/2019129

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