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Cell Mol Life Sci. 2019 Sep 16. doi: 10.1007/s00018-019-03297-w. [Epub ahead of print]

Current perspective on the regulation of FOXO4 and its role in disease progression.

Author information

1
Department of Pathogenic Biology, Faculty of Medicine, Qingdao University, Qingdao, China.
2
Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines: Physiology, Faculty of Medicine, Qingdao University, Qingdao, China.
3
Department of Pathogenic Biology, Faculty of Medicine, Qingdao University, Qingdao, China. qdluobing@163.com.

Abstract

Forkhead box O4 (FOXO4) is a member of the FOXO family that regulates a number of genes involved in metabolism, cell cycle, apoptosis, and cellular homeostasis via transcriptional activity. It also mediates cell responses to oxidative stress and treatment with antitumor agents. The expression of FOXO4 is repressed by microRNAs in multiple cancer cells, while FOXO4 function is regulated by post-translational modifications and interaction with other proteins. The deregulation of FOXO4 is closely linked to the progression of several types of cancer, senescence, and other diseases. In this review, we present recent findings on the regulation of FOXO4 in physiological and pathological conditions and provide an overview of the complex role of FOXO4 in disease development and response to therapy.

KEYWORDS:

Apoptosis; Cancer; Cell proliferation; Drug response; FOXO4

PMID:
31529218
DOI:
10.1007/s00018-019-03297-w

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