Send to

Choose Destination
Biosci Trends. 2019;13(4):286. doi: 10.5582/bst.2019.01241.

Challenges and advances in stem cell therapy.

Tang W1,2.

Author information

International Health Care Center, National Center for Global Health and Medicine.
Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, the University of Tokyo.


After decades of research, stem cells have shown tremendous promise to treat a range of diseases, such as heart disease, diabetes, and neurodegenerative disease. However, many challenges remain in their transformation from bench to bedside, such as the potential risk of tumorigenicity from undifferentiated human induced pluripotent stem cells (hiPSC), the lack of large-scale culture systems for clinical treatment, and the inconvenience of cell therapy itself. "Cell sheet technology" and secretome therapy represent advances in these regards. With gradual breakthroughs in theory and technology, stem cell therapy will lead to a new medical revolution in the coming era.


Stem cell; cell sheet; regenerative medicine; secretome; tissue engineering

Free full text

Supplemental Content

Full text links

Icon for J-STAGE, Japan Science and Technology Information Aggregator, Electronic
Loading ...
Support Center