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J R Soc Med. 2019 Oct;112(10):424-427. doi: 10.1177/0141076819865863. Epub 2019 Sep 17.

Translational glycobiology: from bench to bedside.

Author information

1
The Molecular and Clinical Sciences Research Institute, St George's University of London, London SW17 0RE, UK.
2
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston 02115, USA.
3
Faculty of Pharmacy and Biochemistry, University of Zagreb, HR-10000 Zagreb, Croatia.
4
Department of Microbiology and Immunology, University of Leuven, KU Leuven, BE-3000 Leuven, Belgium.
5
Institute of Molecular Pathology and Immunology, University of Porto, 4200-135 Porto, Portugal.
6
National Institute for Bioprocessing Research and Training, Dublin A94 X099, Ireland.

Abstract

The importance of sugars to protein function is real and is of significant clinical relevance. Technology advances enable large population studies to be carried out, shedding light on individual sugar variation and variations with time. Three-dimensional mass spectroscopy on solid pathological specimens is going to open up a whole new world of pathology visualisation. The door is now open to exploit carbohydrate recognition in new therapeutics by identifying novel biomarkers in cancer to aid diagnosis, and also providing therapeutic targets for treatment. Glycan age correlates with biological age. This means we can map the reversal of biological age with exercise and diet.

KEYWORDS:

Allergy; immunology

PMID:
31526214
DOI:
10.1177/0141076819865863

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