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Nat Prod Res. 2019 Sep 16:1-6. doi: 10.1080/14786419.2019.1666387. [Epub ahead of print]

Hositisines A and B, new alkaloids from the stems of Ormosia hosiei Hemsl. et Wils.

Author information

1
College of Plant Protection, Fujian Agriculture and Forestry University , Fuzhou , People's Republic of China.
2
Fujian Colleges and University Engineering Research Institute of Conservation & Utilization of Natural Bioresources, Fujian Agriculture and Forestry University , Fuzhou , People's Republic of China.
3
College of Pharmacy, Fujian University of Traditional Chinese Medicine , Fuzhou , People's Republic of China.

Abstract

Two new alkaloids, named hositisines A (1) and B (2), with two known alkaloids (3 and 4) were isolated from the stems of Ormosia hosiei Hemsl. et Wils. Their structures were confirmed by UV, HRESIMS, NMR spectra. The absolute configurations of 1 and 2 were determined by quantum ECD calculation and ECD, respectively. Compounds 1-3 could significantly reduce the LDH release at the concentration 50 μM, which showed they could strongly protect the PC12 cells exposed to oxygen and glucose deprivation/reoxygenation (OGD/R) injury.

KEYWORDS:

LDH release; OGD; Ormosia; Ormosia hosiei; PC12; alkaloid

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