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J Res Med Sci. 2019 Aug 28;24:72. doi: 10.4103/jrms.JRMS_804_16. eCollection 2019.

The glucose metabolism disorder and dyslipidemia among girls with different phenotype polycystic ovary syndrome.

Author information

1
Department of Midwifery, Maternal-Fetal Medicine Research Center, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran.
2
Community Based Psychiatric Care Research Centre, Department of Midwifery, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran.
3
Department of Internal Medicine, Endocrine and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Abstract

Background:

This study aimed to determine the prevalence of glucose metabolism disorder and dyslipidemia in 14-18-year-old girls with different phenotype polycystic ovary syndrome (PCOS).

Materials and Methods:

This descriptive, cross-sectional study was conducted on 3200 high-school adolescents aged 14-18 years in Shiraz in 2010. Selected parameters of metabolic syndrome (fasting blood glucose, glucose tolerance test [GTT], insulin level, triglyceride (TG), cholesterol, and high-density lipoprotein [HDL]), based on adult treatment panel ะจ definition criteria, were compared between the "PCOS" and control groups.

Results:

Results were compared at four main phenotypes. The level of serum TG was increased in the Phenotype B (P = 0.03) and Phenotype D (P = 0.01), compared to the control group. Cholesterol and low-density lipoprotein levels (P < 0.05) and GTT (P > 0.05) were increased, and HDL was decreased (was below 50) in all the four phenotypes and the control group (P > 0.05).

Conclusion:

The risk of metabolic alterations of glucose metabolism disorder and dyslipidemia in PCOS adolescents was more than non-PCOS counterparts.

KEYWORDS:

Metabolic syndrome; phenotype; polycystic ovarian syndrome

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