Format

Send to

Choose Destination
Neuron. 1988 May;1(3):201-9.

The organization of cytoplasm at the presynaptic active zone of a central nervous system synapse.

Author information

1
Department of Neurology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106.

Abstract

The axoplasm at the presynaptic active zone of excitatory synapses between parallel fibers and Purkinje cell spines contains a meshwork of distinct filaments intermingled with synaptic vesicles, seen most clearly after the rapid freezing, freeze-etch technique of tissue preparation. One set of filaments extends radially from synaptic vesicles and intersects similar filaments associated with vesicles as well as larger filaments arising from the presynaptic membrane. The small, vesicle-associated filaments appear to link synaptic vesicles to one another and to enmesh them in the vicinity of the synaptic junction. The vesicle-associated filaments could be synapsin I because they have the same molecular dimensions and are distributed in the same pattern as synapsin I immunoreactivity.

PMID:
3152289
DOI:
10.1016/0896-6273(88)90140-7
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center