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Bioelectromagnetics. 2019 Oct;40(7):498-511. doi: 10.1002/bem.22217. Epub 2019 Sep 15.

Early-Life Exposure to Pulsed LTE Radiofrequency Fields Causes Persistent Changes in Activity and Behavior in C57BL/6 J Mice.

Author information

1
Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Chilton, Oxfordshire, UK.
2
Physics Group, EMFcomp Limited, Harwell Campus, Harwell, Oxfordshire, UK.
3
Department of Environmental Health, National Institute of Public Health, Regional Center Iasi, Iasi, Romania.

Abstract

Despite much research, gaps remain in knowledge about the potential health effects of exposure to radiofrequency (RF) fields. This study investigated the effects of early-life exposure to pulsed long term evolution (LTE) 1,846 MHz downlink signals on innate mouse behavior. Animals were exposed for 30 min/day, 5 days/week at a whole-body average specific energy absorption rate (SAR) of 0.5 or 1 W/kg from late pregnancy (gestation day 13.5) to weaning (postnatal day 21). A behavioral tracking system measured locomotor, drinking, and feeding behavior in the home cage from 12 to 28 weeks of age. The exposure caused significant effects on both appetitive behaviors and activity of offspring that depended on the SAR. Compared with sham-exposed controls, exposure at 0.5 W/kg significantly decreased drinking frequency (P ≤ 0.000) and significantly decreased distance moved (P ≤ 0.001). In contrast, exposure at 1 W/kg significantly increased drinking frequency (P ≤ 0.001) and significantly increased moving duration (P ≤ 0.005). In the absence of other plausible explanations, it is concluded that repeated exposure to low-level RF fields in early life may have a persistent and long-term effect on adult behavior. Bioelectromagnetics. 2019;40:498-511. © 2019 The Authors. Bioelectromagnetics Published by Wiley Periodicals, Inc.

KEYWORDS:

activity; brain; electromagnetic fields; locomotion; rodent

PMID:
31522469
PMCID:
PMC6790696
DOI:
10.1002/bem.22217
[Indexed for MEDLINE]
Free PMC Article

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