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Iran J Allergy Asthma Immunol. 2019 Jun 8;18(3):251-261. doi: 10.18502/ijaai.v18i3.1118.

Interleukin-18 Polymorphisms Deficiency Association with Asthma Risk: An Update Meta-analysis.

Author information

1
Department of Preventive Medicine, North Sichuan Medical College, Nanchong, Sichuan, China AND Department of Forensic Medicine, North Sichuan Medical College, Nanchong, Sichuan, China. 244933432@qq.com.
2
Department of Criminal Science and Technology, Chongqing Police College, Chongqing, China. xyun2005@163.com.
3
Department of Forensic Medicine, North Sichuan Medical College, Nanchong, Sichuan, China. 896514886@qq.com.
4
Department of Forensic Medicine, North Sichuan Medical College, Nanchong, Sichuan, China. 857123409@qq.com.
5
Department of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China. yingma1314@126.com.
6
Department of Forensic Medicine, North Sichuan Medical College, Nanchong, Sichuan, China. xyun2005@163.com.

Abstract

Growing evidence indicated conflicting results that Interleukin-18 (IL-18) promoter polymorphisms rs1946518 (A-607C), rs187238 (G-137C) and rs549908 (A-105C) were associated with asthma risk. The aim of this study is to comprehensively evaluate the IL-18 polymorphisms and asthma by a systematic review and meta-analysis. A total of 12 studies testing the association between these polymorphisms and asthma were examined (8 studies for A-607C, 8 studies for G-137C, and 4 studies for A-105C) in the update meta-analysis, up to Dec 30, 2017. Summary odds ratios (ORs) and 95% confidence intervals (CI) were used to estimate the strength of association between each polymorphism and asthma using fixed- and random-effects models when appropriate. Heterogeneity and publication bias were evaluated. The meta-analysis results indicated that any allele frequencies of the IL-18 polymorphisms (A-607C, G-137C and A-105C) was not associated with asthma risk (p>0.05). And no statistically significant association was observed between genotype frequencies of these polymorphisms and asthma under different genetic models (p>0.05). Subgroup analysis results were similar to the main analysis by ethnicity, sample size, genotyping methods, matching criteria and quality score. There was no evidence of publication bias. The present meta-analysis suggests that IL-18 polymorphisms (A-607C, G-137C and A-105C) were unlikely to be associated with asthma risk.

KEYWORDS:

Asthma; Genetic susceptibility; Interleukin-18; Meta-analysis; Single nucleotide polymorphism

PMID:
31522432
DOI:
10.18502/ijaai.v18i3.1118
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