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J Nutr Biochem. 2019 Aug 15;73:108221. doi: 10.1016/j.jnutbio.2019.108221. [Epub ahead of print]

Effects of timing of acute catechin-rich green tea ingestion on postprandial glucose metabolism in healthy men.

Author information

1
Waseda Bioscience Research Institute in Singapore, Waseda University, 11 Biopolis Way, Singapore 138667, Singapore. Electronic address: m-takahashi@aoni.waseda.jp.
2
Graduate School of Advanced Science and Engineering, Waseda University, 2-2 Wakamatsu-cho Shinjuku, Tokyo 1628480, Japan.
3
Faculty of Sport Sciences, Waseda University, 2-579-15 Mikajima Tokorozawa, Saitama 3591192, Japan.
4
Department of Medicine, Tokyo Women's Medical University, Medical Center East, 2-1-10 Nishiogu Arakawa, Tokyo 1168567, Japan.
5
R&D, Core Technology, Biological Science Research, Kao Corporation, 2-1-3 Bunka Sumida, Tokyo 1318501, Japan.
6
Faculty of Science and Engineering, Waseda University, 2-2 Wakamatsu-cho, Shinjuku, Tokyo 1628480, Japan.

Abstract

Green tea polyphenols, particularly catechins, decrease fasting and postprandial glucose. However, no studies have compared the timing of green tea ingestion on glucose metabolism and changes in catechin concentrations. Here, we examined the effects of timing of acute catechin-rich green tea ingestion on postprandial glucose metabolism in young men. Seventeen healthy young men completed four trials involving blood collection in a fasting state and at 30, 60, 120, and 180 min after meal consumption in a random order: 1) morning placebo trial (09:00 h; MP trial), 2) evening placebo trial (17:00 h; EP trial), 3) morning catechin-rich green tea trial (09:00 h; MGT trial), and 4) evening catechin-rich green tea trial (17:00 h; EGT trial). The concentrations of glucose at 120 min (P=.031) and 180 min (P=.013) after meal intake were significantly higher in the MGT trials than in the MP trials. Additionally, the concentration of glucose was significantly lower in EGT trials than in the EP trials at 60 min (P=.014). Moreover, the concentrations of glucose-dependent insulinotropic polypeptide were significantly lower in the green tea trials than in the placebo trials at 30 min (morning: P=.010, evening: P=.006) and 60 min (morning: P=.001, evening: P=.006) after meal intake in both the morning and evening trials. Our study demonstrated that acute ingestion of catechin-rich green tea in the evening reduced postprandial plasma glucose concentrations.

KEYWORDS:

Circadian rhythm; Epigallocatechin gallate; Glucose metabolism; Incretin; Meal timing

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