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Medicine (Baltimore). 2019 Sep;98(37):e17082. doi: 10.1097/MD.0000000000017082.

Breast lesion size assessment in mastectomy specimens: Correlation of cone-beam breast-CT, digital breast tomosynthesis and full-field digital mammography with histopathology.

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Institute of Diagnostic and Interventional Radiology, University Medical Center Goettingen.
Diagnostic Breast Center Goettingen.
Department of Gynecology and Obstetrics, University Medical Center Goettingen.
Department of Gynecology and Obstetrics, Agaplesion Hospital Neu Bethlehem Goettingen.
University of Leipzig, Department of Diagnostic and Interventional Radiology.
Institute for Pathology, University Medical Center Goettingen, Germany.


To compare the accuracy of breast lesion size measurement of cone-beam breast-CT (CBBCT), digital breast tomosynthesis (DBT) and full-field digital mammography (FFDM).Patients scheduled for mastectomy due to at least 1 malignant breast lesion were included. Mastectomy specimens were examined by CBBCT, DBT, FFDM, and histopathology.A total of 94 lesions (40 patients) were included. Histopathological analyses revealed 47 malignant, 6 high-risk, and 41 benign lesions. Mean histopathological lesion size was 20.8 mm (range 2-100). Mean absolute size deviation from histopathology was largest for FFDM (5.3 ± 6.7 mm) and smallest for CBBCT 50 mA, high-resolution mode (4.3 ± 6.7 mm). Differences between imaging modalities did not reach statistical significance (P = .85).All imaging methods tend to overestimate breast lesion size compared to histopathological gold standard. No significant differences were found regarding size measurements, although in tendency CBBCT showed better lesion detection and cT classification over FFDM.

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