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AIDS Patient Care STDS. 2019 Sep;33(9):388-398. doi: 10.1089/apc.2019.0095.

Improving the Youth HIV Prevention and Care Cascades: Innovative Designs in the Adolescent Trials Network for HIV/AIDS Interventions.

Author information

1
Center for Translational Behavioral Science, Florida State University, Tallahassee, Florida.
2
Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
3
Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California.
4
Department of Family Medicine and Public Health Sciences, Wayne State University School of Medicine, Detroit, Michigan.
5
Oregon Social Learning Center, Eugene, Oregon.
6
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.
7
Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts.
8
Department of Psychology, San Diego State University, San Diego, California.
9
Arnold School of Public Health, University of South Carolina, Columbia, South Carolina.
10
Duke Global Health Institute, Duke University, Durham, North Carolina.
11
Friends Research Institute, Los Angeles, California.
12
Department of Healthcare Leadership and Management, Medical University of South Carolina, Charleston, South Carolina.
13
Hackensack Meridian School of Medicine, Seton Hall University, Newark, New Jersey.
14
Department of Psychology, City University of New York-Hunter College, New York, New York.

Abstract

Dramatic decreases in HIV transmission are achievable with currently available biomedical and behavioral interventions, including antiretroviral therapy and pre-exposure prophylaxis. However, such decreases have not yet been realized among adolescents and young adults. The Adolescent Medicine Trials Network (ATN) for HIV/AIDS interventions is dedicated to research addressing the needs of youth at high risk for HIV acquisition as well as youth living with HIV. This article provides an overview of an array of efficient and effective designs across the translational spectrum that are utilized within the ATN. These designs maximize methodological rigor and real-world applicability of findings while minimizing resource use. Implementation science and cost-effectiveness methods are included. Utilizing protocol examples, we demonstrate the feasibility of such designs to balance rigor and relevance to shorten the science-to-practice gap and improve the youth HIV prevention and care continua.

KEYWORDS:

HIV; adolescent; behavioral; methods

PMID:
31517525
PMCID:
PMC6745528
[Available on 2020-09-01]
DOI:
10.1089/apc.2019.0095

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