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Cureus. 2019 Jul 2;11(7):e5063. doi: 10.7759/cureus.5063.

Probiotics and Clostridium Difficile: A Review of Dysbiosis and the Rehabilitation of Gut Microbiota.

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Gastroenterology, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar, IND.
Gastroenterology, Kamineni Academy of Medical Sciences and Research Centre, Hyderabad, IND.
Anaesthesiology, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar, IND.


The basis of this paper is to address the use of probiotics as a novel approach to help treat the growing problem of antibiotic-associated diarrhea (AAD), particularly, Clostridium difficile-associated diarrhea (CDAD). Most of the available data regarding probiotics and their usefulness in treating Clostridium difficile infection (CDI) was collected and analyzed. Studies showed the effectiveness of probiotics in treating and also preventing CDI, as well as other gastrointestinal conditions such as Helicobacter pylori infection and inflammatory bowel disease. Probiotics also have, based on limited research, a comparatively minimal adverse effect profile and can aid in faster recovery from disease. Extensive research has been done on two organisms, Lactobacillus and Saccharomyces, but further research into other effective organisms are needed. More clinical trials also need to be conducted to better understand the side effect profile, optimal dosage, drug interactions, and long-term effects on gut microbiota.


antibiotic-associated diarrhea; clostridium difficile-associated diarrhea; gut microbiota; lactobacillus; probiotics; saccharomyces

Conflict of interest statement

The authors have declared that no competing interests exist.

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