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Ann Pediatr Cardiol. 2019 Sep-Dec;12(3):206-211. doi: 10.4103/apc.APC_151_18.

Percutaneous closure of patent ductus arteriosus with the Nit-Occlud® patent ductus arteriosus device in 268 consecutive cases.

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Department of Interventional Cardiology, Ukrainian Children's Cardiac Center, Kyiv, Ukraine.
P. L. Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine.
Department of Cardiac Surgery, Ludwig Maximilians University, Klinikum der Universität München, Munich, Germany.
Department of Pediatric Cardiology and Intensive Care, Ludwig Maximilians University, Klinikum der Universität München, Munich, Germany.



The pfm Nit-Occlud® patent ductus arteriosus (PDA) device is well established for interventional closure of PDA. However, there are still limited data concerning its efficacy and follow-up in larger patient groups.


This study aimed to evaluate the safety and efficacy of the Nit-Occlud® PDA device, implanted both through transpulmonary and transaortic approach, in a large cohort.


From July 2008 to December 2015, 268 consecutive patients were admitted for transcatheter closure of a PDA and were treated with the Nit-Occlud® coil. Clinical, echocardiographic, and angiographic data were evaluated.


The median age was 5.2 years (range, 5 months to 62 years), and the median weight was 19.3 kg (range: 5.5-97 kg). Ten (3.7%) patients had weight <10 kg. The most common ductus types treated were Krichenko Type E and A (44.0% and 33.2%, respectively). Twelve (4.5%) patients were treated for residual shunting after surgical PDA closure. The median diameter at the narrowest point was 1.5 mm (range: 0.4-4 mm), the median size of the ampulla was 5 mm (range: 1-15 mm), and the median length was 9 mm (range: 2-25 mm). Device implantation could be successfully achieved in all cases. Closure rates documented immediately after the procedure, at 3-10 days, 1 month, and 6 months after intervention were 62%, 95.1%, 97.8%, and 98.5%, respectively. With the exception of one minor thromboembolic event, there were no procedure-related complications.


Closure of PDA with various anatomic variations and sizes can be performed effectively and safely using the Nit-Occlud® coil.


Interventional closure; interventional devices; patent ductus arteriosus

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