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J Oral Maxillofac Pathol. 2019 May-Aug;23(2):310. doi: 10.4103/jomfp.JOMFP_101_19.

Clear cell carcinoma of soft palate- A case report.

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Department of Oral and Maxillofacial Surgery, Purvanchal Institute of Dental Sciences, Gorakhpur, Uttar Pradesh, India.
Department of Prosthodontics, Purvanchal Institute of Dental Sciences, Gorakhpur, Uttar Pradesh, India.
Department of Oral Pathology, SKSS Dental College and Hospital Sarabha, Ludhiana, Punjab, India.


Clear-cell carcinoma (CCC) of the salivary gland is a very rare malignancy. It is recently introduced in the WHO classification of salivary gland tumors. CCC is considered a low-grade tumor, which is commonly seen in elderly females. The most common intraoral sites affected by CCC are palate and tongue. CCC comprises 1% of all salivary gland tumors. CCC has a silent course and a limited nodal metastasis. A hyalinized variant of CCC has good prognosis and requires wide surgical excision with or without adjuvant radiotherapy. Microscopically, it is characterized by the presence of nests of glycogen-rich monomorphic clear cells within a hyalinized stroma. Immunohistochemistry analysis of CCC depicts tumor cells which are positive for epithelial markers and negative for S-100. Here, we report the case of a hyalinized CCC of minor glands of the palate which was misdiagnosed as poorly differentiated squamous cell carcinoma.


Clear-cell carcinoma; hyalinization; immunohistochemistry; minor salivary glands; tumors

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