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J Oral Maxillofac Pathol. 2019 May-Aug;23(2):310. doi: 10.4103/jomfp.JOMFP_101_19.

Clear cell carcinoma of soft palate- A case report.

Author information

1
Department of Oral and Maxillofacial Surgery, Purvanchal Institute of Dental Sciences, Gorakhpur, Uttar Pradesh, India.
2
Department of Prosthodontics, Purvanchal Institute of Dental Sciences, Gorakhpur, Uttar Pradesh, India.
3
Department of Oral Pathology, SKSS Dental College and Hospital Sarabha, Ludhiana, Punjab, India.

Abstract

Clear-cell carcinoma (CCC) of the salivary gland is a very rare malignancy. It is recently introduced in the WHO classification of salivary gland tumors. CCC is considered a low-grade tumor, which is commonly seen in elderly females. The most common intraoral sites affected by CCC are palate and tongue. CCC comprises 1% of all salivary gland tumors. CCC has a silent course and a limited nodal metastasis. A hyalinized variant of CCC has good prognosis and requires wide surgical excision with or without adjuvant radiotherapy. Microscopically, it is characterized by the presence of nests of glycogen-rich monomorphic clear cells within a hyalinized stroma. Immunohistochemistry analysis of CCC depicts tumor cells which are positive for epithelial markers and negative for S-100. Here, we report the case of a hyalinized CCC of minor glands of the palate which was misdiagnosed as poorly differentiated squamous cell carcinoma.

KEYWORDS:

Clear-cell carcinoma; hyalinization; immunohistochemistry; minor salivary glands; tumors

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