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J Oral Maxillofac Pathol. 2019 May-Aug;23(2):304. doi: 10.4103/jomfp.JOMFP_242_17.

Application of in vivo stain of methylene blue as a diagnostic aid in the early detection and screening of oral cancerous and precancerous lesions.

Author information

1
Department of Oral Medicine and Radiology, Rishiraj College of Dental Sciences and Research Centre, Bhopal, Madhya Pradesh, India.
2
MDS Oral Medicine and Radiology Private Practitioner, Khargone, Madhya Pradesh, India.
3
Department of Public Health Dentistry, Rishiraj College of Dental Sciences and Research Centre, Bhopal, Madhya Pradesh, India.
4
Department of Oral and Maxillofacial Pathology, Rishiraj College of Dental Sciences and Research Centre, Bhopal, Madhya Pradesh, India.

Abstract

Background:

Periodic clinical examination of the oral cavity is the mainstay for the early detection of oral cancers which can be further aided by screening individuals with high-risk factors that will identify candidates who should receive treatment to prevent cancer progression and reduce patient mortality. Among the diagnostic tools, in vivo staining is advocated as a simple, inexpensive and fairly sensitive method.

Materials and Methods:

The present study involved the examination of fifty patients suspected of oral malignant or precancerous lesions by methylene blue staining. The results of methylene blue uptake were compared with a simultaneous biopsy of these lesions, while benign epithelial lesions were included as the negative subjects of screening.

Results:

The results revealed a sensitivity of 89%, a specificity of 91%, a positive predictive value of 97% and a negative predictive value of 73%.

Conclusion:

We recommend that methylene blue staining is a useful diagnostic adjunct in a large, community-based oral cancer screening program for high-risk individuals.

KEYWORDS:

Methylene blue; oral cancer; oral precancer; vital staining

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