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Scand J Immunol. 2019 Sep 12. doi: 10.1111/sji.12826. [Epub ahead of print]

Galectin-3 is associated with severe heart failure and death: a hospital based study in Chinese patients.

Author information

1
Department of Cardiovascular, Zhoukou Central Hospital, Zhoukou City, Henan Province, 466000, China.
2
Innoscience Research Sdn Bhd, Jalan USJ 25/1, Subang Jaya, 47650, Selangor Malaysia.
3
Department of Cardiology, Army No.82 Group Military Hospital, Baoding, Hebei, 071000, China.

Abstract

Heart failure (HF) is a serious disease syndrome characterized by elevated pro-inflammatory cytokines and inflammatory mediators presume to have significant contribution on disease progression. Galectins are carbohydrate binding proteins responsible of various physiological functions. Role of galectins in heart failure has been ill defined. In the present case-controls study, 136 patients clinically diagnosed with heart failure and 125 healthy Chinese controls were recruited. Levels of galectins (Gal-1, 3 and 9) and cytokines (IFN-γ, IL-17A, IL-4 and TGF-β) were quantified by ELISA. Increased levels of galectin-1 and 3 was observed in HF patients and associated with clinical severity. In addition, proinflammatory cytokines such as IFN-γ and IL-17A were increased in patients whereas, anti-inflammatory TGFβ was decreased. Galectin-3 was positively correlated with IFN-γ, IL-17A and inversely with TGF-β. Furthermore, ROC curve analysis suggested galectin-3 as a promising biomarker for diagnosis and HF and clinical severity. Interestingly, a two year follow up indicated significant association of elevated galectin-3 with mortality due to HF. In conclusion, galectin-3 associated with HF and clinical manifestations possibly by inducing proinflammatory cytokines and could be a possible biomarker of HF and severe clinical conditions. This article is protected by copyright. All rights reserved.

KEYWORDS:

NYHA; biomarker; cytokine; galectin; heart failure

PMID:
31514240
DOI:
10.1111/sji.12826

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