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Cell Host Microbe. 2019 Sep 11;26(3):309-313. doi: 10.1016/j.chom.2019.08.005.

Manipulating Mosquito Tolerance for Arbovirus Control.

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Institut Pasteur, Insect-Virus Interactions Unit, Department of Virology, UMR2000, CNRS, 75015 Paris, France. Electronic address:
Institut Pasteur, Viruses and RNA Interference Unit, Department of Virology, UMR3569, CNRS, 75015 Paris, France. Electronic address:


The inexorable emergence of mosquito-borne arboviruses and the failure of traditional vector control methods to prevent their transmission have triggered the development of alternative entomological interventions to render mosquito populations incapable of carrying arboviruses. Here, we use a theoretical framework to argue that decreasing mosquito tolerance to arbovirus infection could be a more evolutionarily sustainable disease control strategy than increasing mosquito resistance. Increasing resistance is predicted to select for mutant arboviruses escaping resistance, whereas reducing tolerance should lead to the death of infected vectors and thus select for mosquito-attenuated arbovirus variants that are less transmissible.

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