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Chem Commun (Camb). 2019 Oct 7;55(78):11762-11765. doi: 10.1039/c9cc06468k. Epub 2019 Sep 12.

A water-soluble dual-site fluorescent probe for the rapid detection of cysteine with high sensitivity and specificity.

Author information

1
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000, People's Republic of China. pengyu@lzu.edu.cn.
2
School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People's Republic of China. ywwang@swjtu.edu.cn.
3
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000, People's Republic of China. pengyu@lzu.edu.cn and School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People's Republic of China. ywwang@swjtu.edu.cn.

Abstract

A water-soluble turn-on fluorescent probe has been rationally designed and synthesized to distinguish Cys from Hcy and GSH in less than five seconds. It has high sensitivity and strong anti-interference ability to other amino acids and ions. Its ultra-rapid detection of Cys in aqueous systems could be attributed to dual response sites imparted by the probe.

PMID:
31513186
DOI:
10.1039/c9cc06468k

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