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Chem Commun (Camb). 2019 Sep 26;55(78):11727-11730. doi: 10.1039/c9cc05076k.

Step-by-step real time monitoring of a catalytic amination reaction.

Author information

1
Department of Chemistry, University of Victoria, PO Box 1700 STN CSC, Victoria, BC V8W 2Y2, Canada. E-mail: mcindoe@uvic.ca.

Abstract

The multiple reaction monitoring mode of a triple quadrupole mass spectrometer is used to examine the Buchwald-Hartwig amination reaction at 0.1% catalyst loading in real-time using sequential addition of reagents to probe the individual steps in the cycle. This is a powerful new method for probing reactions under realistic conditions.

PMID:
31512685
DOI:
10.1039/c9cc05076k

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