Send to

Choose Destination
Neurol India. 2019 Jul-Aug;67(4):1097-1099. doi: 10.4103/0028-3886.266258.

Neurogenic Fever in Severe Traumatic Brain Injury Treated with Propranolol: A Case Report.

Author information

Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India.


The causes of intractable fever in severe traumatic brain injury (TBI) patients can be diverse. Neurogenic fever (NF) which is a rare entity can develop due to autonomic dysregulation in the absence of infection or any other cause of fever. It manifests as fever, tachycardia, paroxysmal hypertension, dilated pupils, tachypnea, and extensor posturing in cases of severe TBI, brain neoplasms or brain haemorrhage. We found propranolol to be effective in controlling many of the manifestations of neurogenic fever in our patients with severe TBI. Fever in severe TBI patients is not an uncommon phenomenon, but when intractable with negative fever workup, a central cause should be considered. Propranolol is deemed as one of the most efficacious drugs for managing NF due to dysautonomia. We want to apprise the readers about this entity and its treatment with beta-blockers.


Neurogenic fever; propranolol; severe traumatic brain injury

Free full text

Supplemental Content

Full text links

Icon for Medknow Publications and Media Pvt Ltd
Loading ...
Support Center