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Neurol India. 2019 Jul-Aug;67(4):1093-1096. doi: 10.4103/0028-3886.266289.

Drug Refractory Epilepsy - A Series of Lesions with Triple Pathology.

Author information

1
Department of Neurosurgery, Cardioneurosciences Centre, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
2
Department of Neuropathology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
3
Department of Neurology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.

Abstract

The associations between gangliogliomas, dysembryoplastic neuroepithelial tumors (DNETs), and cortical dysplasias remain debatable. We report five cases of drug refractory epilepsy with temporal lobe lesions. On resection, histopathological examination showed distinctive areas of gangliogliomas and DNETs with cortical dysplasia. The coexistence of the above three lesions as distinct entities in a single lesion is virtually unknown. This points to the presence of a possible etiological relationship among them. Finally, we also delve into a plausible hypothesis for such a pathogenesis.

KEYWORDS:

Cortical dysplasia; dysembryoplastic neuroepithelial tumors; gangliogliomas; triple pathology

PMID:
31512643
DOI:
10.4103/0028-3886.266289
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