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Int J Mycobacteriol. 2019 Jul-Sep;8(3):218-222. doi: 10.4103/ijmy.ijmy_88_19.

A bioinformatics analysis of exosomal microRNAs released following mycobacterial infection.

Author information

1
Department of Molecular Medicine, Institute of Medical Biotechnology, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran.
2
Priority Research Centre for Asthma and Respiratory Disease, Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW, Australia; Airways Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom.
3
Division of Pharmacology, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands.
4
Division of Pharmacology, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University; Immunology Section, Nutricia Research, Utrecht, Netherlands.
5
Division of Pharmacology, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands; Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Abstract

Background:

Tuberculosis (TB) still remains a major health threat worldwide. The current TB diagnostics are suboptimal, and there is a high clinical need for identifying novel biomarkers of disease prevalence. Circulating exosomes have been currently attractive as novel biomarkers in a wide range of pathological conditions.

Methods:

In this study, we performed bioinformatics analysis on the downstream targets of a dysregulated microRNA (miRNA) cluster induced by Bacillus Calmette-Guerin infection of human macrophages to provide greater understanding of their potential roles in disease pathogenesis.

Results:

Our analysis demonstrated that these dysregulated miRNAs have central roles in the host metabolic and energy pathways.

Conclusion:

This suggests that the host miRNA network is perturbed by Mycobacterium to re-patterning host metabolism machinery to favor its intracellular survival. The dysregulated miRNAs can be delivered to local and distal cells by exosomes and thereby modulate their function.

KEYWORDS:

Clusters; exosomal; microRNAs; tuberculosis

PMID:
31512596
DOI:
10.4103/ijmy.ijmy_88_19
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